Hemolytic disease of the newborn (HDN) is a blood disorder where a mother's antibodies attack her baby's red blood cells, causing anemia and jaundice. It is caused by blood type incompatibility between mother and baby, most commonly involving Rh factor or ABO blood groups. The Antibody Screen RBC with Reflex to Identification Titer and Antigen Typing is the most important test for diagnosis during pregnancy.
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Hemolytic disease of the newborn is caused by blood type incompatibility between a pregnant mother and her developing baby. When the baby inherits a blood type from the father that differs from the mother's, particularly involving Rh factor (Rh-positive baby with Rh-negative mother) or ABO blood groups, the mother's immune system may recognize the baby's red blood cells as foreign and produce antibodies against them. These maternal antibodies cross the placenta and destroy the baby's red blood cells, leading to anemia, jaundice, and potentially serious complications if left untreated.
The Antibody Screen RBC with Reflex to Identification Titer and Antigen Typing is the most important test for hemolytic disease of the newborn because it detects maternal antibodies that could attack the baby's red blood cells during pregnancy. This comprehensive screening test identifies whether antibodies are present in the mother's blood, then automatically performs additional testing to identify the specific antibody type, measure antibody levels (titer), and determine antigen typing. Early detection through this test allows healthcare providers to monitor the pregnancy closely, assess the risk level to the baby, and plan appropriate interventions such as increased surveillance, early delivery, or specialized treatments to protect both mother and baby from serious complications.
You should get tested during your first prenatal visit in early pregnancy, typically in the first trimester. All pregnant women should undergo antibody screening as part of routine prenatal care, regardless of previous pregnancy history. If you have a negative Rh blood type, had a previous pregnancy with blood type incompatibility, received a blood transfusion, or experienced bleeding during pregnancy, repeat testing may be necessary later in pregnancy. If initial antibody screening shows positive results, your healthcare provider will recommend additional testing throughout your pregnancy to monitor antibody levels and assess risk to your baby.
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Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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