Congenital afibrinogenemia is an extremely rare inherited bleeding disorder characterized by the complete absence of fibrinogen, a critical blood clotting protein. It is caused by mutations in the FGA, FGB, or FGG genes that prevent the production of functional fibrinogen protein. The Fibrinogen Antigen test is the most important test for diagnosis because it directly measures fibrinogen protein levels in the blood.
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Congenital afibrinogenemia is caused by inherited mutations in one of three genes: FGA, FGB, or FGG. These genes provide instructions for making the three protein chains that combine to form fibrinogen, a critical clotting protein. When both copies of one of these genes are mutated, the body cannot produce any functional fibrinogen, resulting in a complete inability to form stable blood clots and leading to severe bleeding episodes throughout life.
The Fibrinogen Antigen test is the most important test for congenital afibrinogenemia because it directly measures the amount of fibrinogen protein in your blood. In people with this rare genetic disorder, fibrinogen levels are either completely absent (less than 5 mg/dL) or severely reduced, compared to normal levels of 200-400 mg/dL. This test provides definitive evidence of the condition and distinguishes it from other bleeding disorders. The test is essential not only for diagnosis but also for monitoring treatment response when fibrinogen replacement therapy is administered.
You should get tested if you experience unexplained bleeding episodes that seem excessive, such as severe nosebleeds, excessive bleeding from minor cuts, easy bruising, prolonged bleeding after dental procedures, or unusual bleeding after surgery. Testing is especially important if you have a family history of unexplained bleeding disorders or if routine blood clotting tests show abnormal results. Women should get tested if they experience heavy menstrual bleeding or recurrent miscarriages, as these can be early signs of a clotting disorder.
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What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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