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Chronic Kidney Disease (CKD) is a progressive condition where the kidneys gradually lose their ability to filter waste products and excess fluid from the blood. It is caused by damage to the nephrons (kidney filtering units) from conditions like diabetes, high blood pressure, or glomerulonephritis. The Creatinine Serum test is the most important test for CKD diagnosis because it measures waste buildup and calculates eGFR to stage kidney function decline.
Chronic Kidney Disease is caused by damage to the nephrons, the tiny filtering units inside your kidneys that remove waste from your blood. Diabetes and high blood pressure are the two most common causes, accounting for about two-thirds of all CKD cases. Other causes include glomerulonephritis (inflammation of the kidney filters), polycystic kidney disease, prolonged urinary tract obstruction, recurrent kidney infections, and long-term use of certain medications like NSAIDs. Once nephrons are damaged, they cannot repair themselves, and the remaining healthy nephrons must work harder, which can lead to further kidney damage over time.
The Creatinine Serum test is the most important test for Chronic Kidney Disease because it measures creatinine levels in your blood and calculates your eGFR (estimated glomerular filtration rate), which is the gold standard for diagnosing and staging CKD. When your kidneys are damaged, creatinine (a waste product from muscle metabolism) builds up in your blood instead of being filtered out. The eGFR calculation tells doctors exactly how well your kidneys are filtering waste, with lower numbers indicating more advanced kidney disease. The Kidney Function Profile is also essential as it provides comprehensive kidney markers including eGFR, BUN, and electrolytes. For early detection, the Microalbumin Random Urine with Creatinine test detects protein leakage into urine before significant kidney function decline occurs, making it valuable for catching CKD in its earliest stages.
You should get tested if you have diabetes, high blood pressure, heart disease, or a family history of kidney disease, as these are the biggest risk factors for CKD. Get tested immediately if you notice foamy or bubbly urine (indicating protein in urine), swelling in your ankles or feet, persistent fatigue, trouble concentrating, poor appetite, trouble sleeping, or more frequent urination especially at night. People over 60, those with obesity, and individuals who have had recurrent urinary tract infections should also get regular kidney function screening. Because CKD often develops silently without noticeable symptoms until advanced stages, annual testing is recommended for anyone with risk factors even if they feel completely healthy.
What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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