Chronic Kidney Disease Blood Test

What is Chronic Kidney Disease?

Chronic Kidney Disease (CKD) is a progressive condition where the kidneys gradually lose their ability to filter waste products and excess fluid from the blood. It is caused by damage to the nephrons (kidney filtering units) from conditions like diabetes, high blood pressure, or glomerulonephritis. The Creatinine Serum test is the most important test for CKD diagnosis because it measures waste buildup and calculates eGFR to stage kidney function decline.

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What causes Chronic Kidney Disease?

Chronic Kidney Disease is caused by damage to the nephrons, the tiny filtering units inside your kidneys that remove waste from your blood. Diabetes and high blood pressure are the two most common causes, accounting for about two-thirds of all CKD cases. Other causes include glomerulonephritis (inflammation of the kidney filters), polycystic kidney disease, prolonged urinary tract obstruction, recurrent kidney infections, and long-term use of certain medications like NSAIDs. Once nephrons are damaged, they cannot repair themselves, and the remaining healthy nephrons must work harder, which can lead to further kidney damage over time.

What is the best test for Chronic Kidney Disease?

The Creatinine Serum test is the most important test for Chronic Kidney Disease because it measures creatinine levels in your blood and calculates your eGFR (estimated glomerular filtration rate), which is the gold standard for diagnosing and staging CKD. When your kidneys are damaged, creatinine (a waste product from muscle metabolism) builds up in your blood instead of being filtered out. The eGFR calculation tells doctors exactly how well your kidneys are filtering waste, with lower numbers indicating more advanced kidney disease. The Kidney Function Profile is also essential as it provides comprehensive kidney markers including eGFR, BUN, and electrolytes. For early detection, the Microalbumin Random Urine with Creatinine test detects protein leakage into urine before significant kidney function decline occurs, making it valuable for catching CKD in its earliest stages.

When should I get tested for Chronic Kidney Disease?

You should get tested if you have diabetes, high blood pressure, heart disease, or a family history of kidney disease, as these are the biggest risk factors for CKD. Get tested immediately if you notice foamy or bubbly urine (indicating protein in urine), swelling in your ankles or feet, persistent fatigue, trouble concentrating, poor appetite, trouble sleeping, or more frequent urination especially at night. People over 60, those with obesity, and individuals who have had recurrent urinary tract infections should also get regular kidney function screening. Because CKD often develops silently without noticeable symptoms until advanced stages, annual testing is recommended for anyone with risk factors even if they feel completely healthy.

What are the symptoms of Chronic Kidney Disease?
Early-stage Chronic Kidney Disease usually causes no symptoms, which is why blood testing is so important for detection. As kidney function declines, you might experience fatigue and weakness, loss of appetite, difficulty concentrating or mental fogginess, trouble sleeping, muscle cramping especially at night, swollen feet and ankles, puffy eyes especially in the morning, dry and itchy skin, and more frequent urination particularly at night. Advanced CKD can cause nausea and vomiting, shortness of breath, chest pain if fluid builds up around the heart, high blood pressure that is difficult to control, and foamy or bubbly urine indicating protein leakage. Many people do not realize they have kidney disease until it has progressed significantly, making routine screening essential for those at risk.
Who is at risk for Chronic Kidney Disease?
People with diabetes are at the highest risk for CKD, as high blood sugar damages the kidney filters over time. Those with high blood pressure are also at major risk because elevated pressure damages blood vessels in the kidneys. Other high-risk groups include people over age 60, individuals with heart disease or a history of heart attack or stroke, those with a family history of kidney disease, people with obesity, smokers, and individuals who have had recurrent kidney infections or urinary tract problems. African Americans, Hispanics, Native Americans, and Asian Americans face higher risk due to increased rates of diabetes and high blood pressure in these populations. Long-term use of NSAIDs like ibuprofen or naproxen also increases kidney disease risk.
What happens if Chronic Kidney Disease is left untreated?
Untreated Chronic Kidney Disease progresses through five stages, eventually leading to kidney failure (end-stage renal disease) where the kidneys can no longer sustain life without dialysis or kidney transplant. As CKD advances, dangerous waste products and fluid build up in your body, causing severe complications including life-threatening heart disease and stroke (the leading cause of death in CKD patients), severe anemia causing extreme fatigue and weakness, bone disease and fractures due to mineral imbalances, fluid accumulation in the lungs making breathing difficult, dangerous potassium levels that can cause irregular heartbeat or cardiac arrest, and weakened immune system increasing infection risk. CKD also increases the risk of developing gout, nerve damage, liver problems, and significantly reduces life expectancy. Early detection and treatment can slow or even halt progression, making testing crucial for anyone at risk.
Can Chronic Kidney Disease be diagnosed with a blood test?
Yes, Chronic Kidney Disease is primarily diagnosed through blood tests that measure how well your kidneys are filtering waste from your blood. The Creatinine Serum test is the cornerstone of CKD diagnosis because it measures creatinine levels and calculates your eGFR, which directly shows your kidney filtering capacity. Blood tests also measure BUN (blood urea nitrogen), another waste product that builds up when kidneys fail, as well as electrolytes like potassium and phosphorus that become imbalanced in kidney disease. While urine tests (like the Microalbumin test) complement blood work by detecting early kidney damage through protein leakage, blood tests remain the primary diagnostic tool. The eGFR calculated from blood creatinine is used to stage CKD from Stage 1 (mild damage with normal filtration) to Stage 5 (kidney failure), making blood testing essential for both diagnosis and ongoing monitoring.
How is Chronic Kidney Disease treated?
Chronic Kidney Disease treatment focuses on slowing progression and managing complications since kidney damage cannot be reversed. If you have diabetes or high blood pressure (the main causes), controlling these conditions with medications like ACE inhibitors or ARBs is critical to protecting remaining kidney function. Your doctor will prescribe medications to manage complications such as phosphate binders to control mineral levels, erythropoietin-stimulating agents for anemia, vitamin D supplements, blood pressure medications, cholesterol-lowering drugs, and diuretics to reduce fluid buildup. Dietary changes are essential, including limiting protein, sodium, potassium, and phosphorus based on your CKD stage. As kidney function declines toward failure, you will need preparation for dialysis or kidney transplant evaluation. Regular blood testing to monitor kidney function, electrolytes, and related markers is crucial throughout treatment to adjust medications and slow disease progression.
How can I prevent Chronic Kidney Disease?
Preventing Chronic Kidney Disease centers on controlling the two biggest risk factors: diabetes and high blood pressure. If you have diabetes, keep your blood sugar in target range through medication, diet, and regular monitoring. Control your blood pressure below 130/80 through lifestyle changes and medication if needed. Maintain a healthy weight through regular physical activity and balanced diet, as obesity increases CKD risk significantly. Quit smoking, which damages blood vessels in the kidneys and accelerates disease progression. Avoid long-term use of NSAIDs like ibuprofen and naproxen, which can damage kidneys over time. Stay hydrated with water rather than sugary drinks. Limit salt intake to reduce blood pressure. Get regular kidney function blood tests if you have risk factors, as early detection allows intervention before significant damage occurs. Managing heart disease and following medication instructions carefully also protects kidney health.
What can I do at home to support kidney health with Chronic Kidney Disease?
Supporting kidney health at home starts with following a kidney-friendly diet that limits sodium to reduce fluid retention and blood pressure, restricts protein to decrease waste buildup your kidneys must filter, and controls potassium and phosphorus based on your blood test results. Drink adequate fluids unless your doctor restricts fluid intake in advanced stages. Monitor your blood pressure daily at home and keep a log to share with your doctor. Stay physically active within your energy limits, as exercise helps control blood pressure, blood sugar, and weight. Track your medications carefully and take them exactly as prescribed, especially blood pressure and diabetes medications. Avoid herbal supplements and over-the-counter medications without consulting your doctor, as many can harm kidneys. Limit alcohol consumption and quit smoking. Get adequate sleep and manage stress through relaxation techniques. Most importantly, get regular blood tests to monitor your kidney function and catch any decline early so treatment can be adjusted promptly.
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If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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