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Autoimmune thyroid diseases are conditions where the immune system mistakenly attacks the thyroid gland, causing either underactive thyroid (Hashimoto's thyroiditis) or overactive thyroid (Graves' disease). They are caused by abnormal production of thyroid antibodies including thyroid peroxidase antibodies (TPO) and thyroglobulin antibodies that damage thyroid tissue. The ANA Screen IFA with Reflex to Titer and Pattern is the most important complementary test for detecting broader autoimmune activity associated with thyroid disease.
Autoimmune thyroid disease is caused by the immune system producing antibodies that attack the thyroid gland. In Hashimoto's thyroiditis, thyroid peroxidase antibodies (TPO) and thyroglobulin antibodies destroy thyroid cells, leading to hypothyroidism. In Graves' disease, thyroid-stimulating immunoglobulins (TSI) overstimulate the thyroid, causing hyperthyroidism. Genetic factors, environmental triggers, and hormonal changes can all contribute to developing these autoimmune conditions.
The ANA Screen IFA with Reflex to Titer and Pattern is the most important complementary test for autoimmune thyroid disease because it detects antinuclear antibodies that indicate broader autoimmune activity in your body. This test helps identify if your immune system is producing antibodies against your own tissues, which is common in people with Hashimoto's thyroiditis and Graves' disease. Your doctor will also order thyroid-specific antibody tests like TPO and thyroglobulin antibodies, along with thyroid function tests (TSH, Free T3, Free T4) to get a complete picture of your thyroid health and autoimmune status.
You should get tested if you experience unexplained weight changes, persistent fatigue, sensitivity to heat or cold, irregular heartbeat, or changes in mood and energy levels. Testing is also important if you have a family history of thyroid problems, are pregnant or planning pregnancy, or have been diagnosed with another autoimmune condition like type 1 diabetes or celiac disease. Women over 60 and people with other autoimmune conditions are at higher risk and should consider regular screening even without obvious symptoms.
What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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