Question 1

What is Autoimmune Pancreatitis?

Accepted Answer

Autoimmune pancreatitis is a rare form of chronic pancreatic inflammation where the immune system mistakenly attacks pancreatic tissue. It is caused by the immune system producing antibodies that specifically target pancreatic exocrine cells, leading to organ dysfunction. The Pancreatic Exocrine Cell Antibody test is the most important test for diagnosis.

Question 2

What causes autoimmune pancreatitis?

Accepted Answer

Autoimmune pancreatitis is caused by the immune system mistakenly attacking the pancreas, producing antibodies that target pancreatic exocrine cells. Unlike typical pancreatitis triggered by gallstones or alcohol, this condition involves an autoimmune response where your body's defense system turns against pancreatic tissue. The exact trigger for this immune dysfunction remains unclear, but it leads to chronic inflammation and potential organ damage that requires different treatment than other forms of pancreatitis.

Question 3

What is the best test for autoimmune pancreatitis?

Accepted Answer

The Pancreatic Exocrine Cell Antibody test is the most important blood test for autoimmune pancreatitis because it specifically detects antibodies attacking pancreatic tissue. This test identifies the autoimmune component that distinguishes this condition from other pancreatic disorders and pancreatic cancer. The presence of these antibodies, combined with imaging findings and clinical symptoms, provides essential confirmation of the autoimmune nature of the inflammation. This diagnostic information guides treatment decisions, as autoimmune pancreatitis typically responds to immunosuppressive therapy rather than standard pancreatitis treatments.

Question 4

When should I get tested for autoimmune pancreatitis?

Accepted Answer

You should get tested if you experience persistent upper abdominal pain, unexplained weight loss, jaundice with yellowing skin or eyes, or new-onset diabetes without typical risk factors. Testing is especially important if you have other autoimmune conditions or if imaging studies show unusual pancreatic enlargement. Early diagnosis through blood testing helps distinguish autoimmune pancreatitis from pancreatic cancer and other serious conditions, allowing for appropriate immunosuppressive treatment that can prevent permanent pancreatic damage.

Question 5

What are the symptoms of autoimmune pancreatitis?

Accepted Answer

Autoimmune pancreatitis causes persistent upper abdominal pain that may radiate to your back, unexplained weight loss, and fatigue. You might notice jaundice with yellowing of your skin and eyes, dark urine, or pale-colored stools. Some people develop new-onset diabetes or experience digestive problems including nausea and poor appetite. Unlike acute pancreatitis, symptoms typically develop gradually over weeks to months rather than appearing suddenly.

Question 6

Who is at risk for autoimmune pancreatitis?

Accepted Answer

Autoimmune pancreatitis most commonly affects men over age 50, though it can occur at any age. People with other autoimmune conditions such as inflammatory bowel disease, primary sclerosing cholangitis, or Sjogren syndrome have increased risk. Those with a family history of autoimmune diseases may be more susceptible. The condition is relatively rare compared to other forms of pancreatitis, but recognizing risk factors helps with early diagnosis and treatment.

Question 7

What happens if autoimmune pancreatitis is left untreated?

Accepted Answer

Untreated autoimmune pancreatitis leads to progressive pancreatic damage and permanent scarring that impairs both digestive enzyme production and insulin secretion. You may develop chronic diabetes requiring lifelong insulin therapy and malabsorption problems causing nutritional deficiencies. The chronic inflammation can spread to bile ducts and other organs, and the condition can be mistaken for pancreatic cancer, leading to unnecessary surgery. Early diagnosis and immunosuppressive treatment can reverse inflammation and prevent these serious complications.

Question 8

Can autoimmune pancreatitis be diagnosed with a blood test?

Accepted Answer

Autoimmune pancreatitis can be detected through blood testing for pancreatic exocrine cell antibodies, which reveal the autoimmune nature of the inflammation. Blood tests also show elevated IgG4 levels in many cases, providing additional diagnostic support. While imaging studies and sometimes biopsy are needed for complete diagnosis, blood testing provides crucial evidence of autoimmune activity and helps distinguish this condition from pancreatic cancer and other pancreatic disorders. The Pancreatic Exocrine Cell Antibody test is specifically designed to identify this autoimmune process.

Question 9

How is autoimmune pancreatitis treated?

Accepted Answer

Autoimmune pancreatitis is treated with immunosuppressive medications, primarily corticosteroids like prednisone, which calm the immune system attack on pancreatic tissue. Most patients respond dramatically to steroid therapy within weeks, with symptoms improving and inflammation resolving. Treatment typically continues for several months, with gradual dose reduction under medical supervision. Some people require additional immunosuppressive medications if steroids alone are insufficient or to prevent relapse. This treatment approach differs completely from other forms of pancreatitis and highlights why accurate diagnosis through antibody testing is essential.

Question 10

How can I prevent autoimmune pancreatitis?

Accepted Answer

Autoimmune pancreatitis cannot be prevented because the exact triggers for the immune system malfunction are unknown. However, if you have other autoimmune conditions, maintaining regular medical care and monitoring can help detect pancreatic involvement early. Once diagnosed, following your prescribed immunosuppressive treatment regimen helps prevent relapses and progressive pancreatic damage. Some people require long-term maintenance therapy to keep the autoimmune inflammation under control and preserve pancreatic function.

Question 11

What can I do at home for autoimmune pancreatitis?

Accepted Answer

While autoimmune pancreatitis requires medical treatment with immunosuppressive medications, you can support your recovery by following a low-fat diet to reduce pancreatic workload and eating smaller, frequent meals. Avoid alcohol completely, as it adds stress to the inflamed pancreas. Stay well-hydrated and take prescribed pancreatic enzyme supplements if your doctor recommends them to aid digestion. Managing stress through relaxation techniques may help, as stress can affect immune function. Always take your prescribed medications as directed and attend follow-up appointments to monitor treatment response and prevent relapses.

Question 12

How’s this work?

Accepted Answer

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Question 13

How do I know which test to get?

Accepted Answer

In the test options, find the test you want.
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Question 14

When will my lab results be available?

Accepted Answer

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know.
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Question 15

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Accepted Answer

Absolutely! We totally understand that errors can happen. No worries, we're here to help you.
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Question 16

Do you accept health insurance?

Accepted Answer

Only HSA & FSA is accepted.
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Question 17

Can I cancel my order?

Accepted Answer

Yes.
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Question 18

How can I find a lab location near me?

Accepted Answer

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached!
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Autoimmune Pancreatitis Blood Test

What is Autoimmune Pancreatitis?

What causes autoimmune pancreatitis?

What is the best test for autoimmune pancreatitis?

When should I get tested for autoimmune pancreatitis?

References

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