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Atrophic thyroiditis is a form of autoimmune thyroid disease where the thyroid gland shrinks and loses function over time. It is caused by the immune system producing antibodies against thyroid peroxidase (TPO), an enzyme essential for thyroid hormone production. The Thyroid Peroxidase (TPO) Antibodies test is the most important test for diagnosing atrophic thyroiditis.
Atrophic thyroiditis is caused by an autoimmune response where your immune system mistakenly produces antibodies that attack the thyroid gland. These antibodies, particularly thyroid peroxidase (TPO) antibodies, target and destroy thyroid tissue over time. Unlike other forms of Hashimoto's thyroiditis that cause thyroid enlargement, atrophic thyroiditis causes the thyroid to shrink and gradually lose its ability to produce thyroid hormones, leading to hypothyroidism.
The Thyroid Peroxidase (TPO) Antibodies test is the most important test for atrophic thyroiditis because it detects the specific antibodies attacking your thyroid gland. Elevated TPO antibody levels confirm the autoimmune nature of the condition and distinguish it from other causes of thyroid problems. This test is typically performed alongside thyroid function tests (TSH, T3, T4) to provide a complete picture of thyroid health. Together, positive TPO antibodies combined with elevated TSH levels confirm the diagnosis and help your healthcare provider determine the best treatment approach for managing your condition.
You should get tested if you experience symptoms of hypothyroidism such as unexplained fatigue, weight gain, sensitivity to cold, dry skin, hair loss, or depression. Testing is also important if you have a family history of autoimmune thyroid disease or other autoimmune conditions. Early detection through TPO antibody testing allows for timely treatment to prevent complications and helps you manage symptoms before they significantly impact your quality of life.
What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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