Question 1

What is aspirin resistance?

Accepted Answer

Aspirin resistance is a condition where the body does not respond adequately to aspirin's blood-thinning and antiplatelet effects, potentially reducing its protective benefits for cardiovascular health. It is caused by continued platelet aggregation and thromboxane production despite regular aspirin therapy. The AspirinWorks 11-Dehydrothromboxane B2 test is the most important test for diagnosis because it directly measures platelet activity and thromboxane metabolites.

Question 2

What causes aspirin resistance?

Accepted Answer

Aspirin resistance is caused by genetic variations, increased platelet turnover, insufficient dosing, and non-compliance with aspirin therapy. Genetic polymorphisms affecting platelet receptors and cyclooxygenase enzymes can reduce aspirin's ability to block thromboxane production. Other factors include interactions with other medications like NSAIDs, inflammation, diabetes, and elevated cholesterol levels that interfere with aspirin's antiplatelet effects.

Question 3

What is the best test for aspirin resistance?

Accepted Answer

The AspirinWorks 11-Dehydrothromboxane B2 (11-dhTXB2) with Creatinine test is the most important test for aspirin resistance because it directly measures the metabolite of thromboxane B2, which reflects platelet activity and aggregation. When aspirin works effectively, it blocks thromboxane production and keeps platelet aggregation low. Elevated 11-dhTXB2 levels indicate that platelets continue to produce thromboxane despite aspirin therapy, confirming resistance. The creatinine measurement ensures accurate interpretation by accounting for kidney function, making this the gold standard for detecting whether your aspirin therapy is providing adequate heart protection.

Question 4

When should I get tested for aspirin resistance?

Accepted Answer

You should get tested if you are taking daily aspirin for heart attack or stroke prevention but have experienced a cardiovascular event while on therapy, have a family history of heart disease despite aspirin use, or your doctor wants to verify that your aspirin regimen is working effectively. Testing is especially important if you have diabetes, high cholesterol, or chronic inflammation, as these conditions can interfere with aspirin's effectiveness and increase your risk of treatment failure.

Question 5

What are the symptoms of aspirin resistance?

Accepted Answer

Aspirin resistance typically has no direct symptoms because it is a laboratory finding rather than a condition you can feel. However, the consequences of aspirin resistance can manifest as cardiovascular events such as heart attacks, strokes, or blood clots despite taking aspirin regularly. You might notice chest pain, shortness of breath, sudden weakness, or numbness that suggests your aspirin therapy is not providing adequate protection against these serious complications.

Question 6

Who is at risk for aspirin resistance?

Accepted Answer

People with diabetes, high cholesterol, chronic kidney disease, and inflammatory conditions are at higher risk for aspirin resistance. Those taking certain medications like NSAIDs or proton pump inhibitors may experience reduced aspirin effectiveness. Genetic factors also play a role, with some people inheriting variations in genes that control platelet function and aspirin metabolism. Smokers, obese individuals, and those with a history of cardiovascular disease despite aspirin therapy should consider testing for resistance.

Question 7

What happens if aspirin resistance is left untreated?

Accepted Answer

Untreated aspirin resistance significantly increases your risk of heart attacks, strokes, and blood clots because your platelets continue to aggregate and form dangerous clots despite aspirin therapy. You may be falsely reassured that you are protected when you are actually at high cardiovascular risk. Detecting aspirin resistance early allows your doctor to adjust your treatment plan, potentially switching to alternative antiplatelet medications like clopidogrel or adding additional therapies to provide adequate protection against life-threatening cardiovascular events.

Question 8

Can aspirin resistance be diagnosed with a blood test?

Accepted Answer

Aspirin resistance is diagnosed with a specialized blood test that measures 11-dhTXB2, a metabolite that reflects ongoing platelet activity and thromboxane production. This urine-based test provides a reliable indicator of whether aspirin is effectively blocking platelet aggregation. Unlike standard blood tests, this specialized assay specifically measures the biochemical pathway that aspirin targets, giving you and your doctor clear evidence about whether your aspirin therapy is working or if alternative treatments are needed for cardiovascular protection.

Question 9

How is aspirin resistance treated?

Accepted Answer

Aspirin resistance is treated by adjusting medication regimens to ensure adequate antiplatelet protection. Your doctor may increase your aspirin dose, switch you to alternative antiplatelet medications like clopidogrel or ticagrelor, or add a second antiplatelet agent for dual therapy. Addressing underlying conditions like diabetes, high cholesterol, and inflammation can also improve aspirin responsiveness. Avoiding NSAIDs and ensuring medication compliance are critical steps in managing aspirin resistance and reducing your cardiovascular risk.

Question 10

How can I prevent aspirin resistance?

Accepted Answer

Preventing aspirin resistance involves taking aspirin consistently as prescribed, avoiding NSAIDs that can interfere with aspirin's effectiveness, and managing underlying health conditions like diabetes and high cholesterol. Maintaining a heart-healthy lifestyle with regular exercise, a balanced diet rich in omega-3 fatty acids, and smoking cessation can improve platelet function and aspirin responsiveness. Regular monitoring with your healthcare provider ensures that your aspirin therapy remains effective, and testing can identify resistance early so treatment adjustments can be made promptly.

Question 11

What lifestyle changes help with aspirin resistance?

Accepted Answer

Lifestyle changes that support cardiovascular health can improve aspirin effectiveness and reduce resistance. Focus on a Mediterranean-style diet rich in fruits, vegetables, whole grains, and omega-3 fatty acids from fish, which naturally support healthy platelet function. Regular physical activity improves circulation and reduces inflammation that can interfere with aspirin. Quit smoking, limit alcohol intake, manage stress through relaxation techniques, and maintain a healthy weight to optimize your body's response to aspirin therapy and lower your overall cardiovascular risk.

Question 12

How’s this work?

Accepted Answer

Getting your blood test with us is easy, private & backed by the power of science.Long story short:
            
                In the test options, use the filters or search box to narrow your choices and find the test you want.
                If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
                Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
                If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
                When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
                Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
                You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
                If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

Question 13

How do I know which test to get?

Accepted Answer

In the test options, find the test you want.
            If you’re not sure which test to get, we can lend a hand in finding the right option.
            Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

Question 14

When will my lab results be available?

Accepted Answer

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know.
            After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop!
            If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Question 15

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Accepted Answer

Absolutely! We totally understand that errors can happen. No worries, we're here to help you.
            Just reach out to us via text at 754-799-7833 or shoot us an email at
            support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update.
            Our awesome team will jump right in and make sure everything is sorted out and accurate for you.
            There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.
            Our lab requires an address to be listed to generate an order.

Question 16

Do you accept health insurance?

Accepted Answer

Only HSA & FSA is accepted.
            Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.
            This policy applies to all insurance companies, including federal health insurance programs like Medicare.
            If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Question 17

Can I cancel my order?

Accepted Answer

Yes.
            We get it – sometimes your needs change.
            As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.
            If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com.
            You can read more about our cancellation policy here.

Question 18

How can I find a lab location near me?

Accepted Answer

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached!
            You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).
            Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.
            If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

Aspirin Resistance Blood Test

What is Aspirin resistance?

What causes aspirin resistance?

What is the best test for aspirin resistance?

When should I get tested for aspirin resistance?

References

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