Aortic Valve Stenosis Blood Test

What is Aortic valve stenosis?

Aortic valve stenosis is a heart condition where the aortic valve narrows and restricts blood flow from the heart to the rest of the body. It is caused by progressive calcification of the valve leaflets, often accelerated by elevated lipoprotein(a) levels. The Lipoprotein(a) test is the most important blood test for assessing cardiovascular risk factors that contribute to valve calcification and stenosis progression.

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What causes aortic valve stenosis?

Aortic valve stenosis is caused by progressive calcification and thickening of the aortic valve leaflets, which narrows the valve opening and restricts blood flow. The most common cause in older adults is age-related calcium buildup on the valve, similar to hardening of the arteries. Elevated lipoprotein(a) levels significantly accelerate this calcification process by depositing calcium on the valve tissue. In younger people, congenital heart defects like bicuspid aortic valve or rheumatic fever from untreated strep infections can also cause valve damage and stenosis over time.

What is the best test for aortic valve stenosis?

The Lipoprotein(a) test is the most important blood test for aortic valve stenosis because it measures a specific lipoprotein strongly linked to valve calcification and disease progression. Elevated lipoprotein(a) levels directly contribute to calcium deposits forming on the aortic valve, making this test essential for assessing your cardiovascular risk factors. While aortic valve stenosis is primarily diagnosed through echocardiograms and imaging studies that visualize the valve structure and blood flow, the Lipoprotein(a) blood test helps identify patients at higher risk for developing or worsening stenosis. This information allows your healthcare provider to monitor progression and develop strategies to manage risk factors that accelerate valve deterioration.

When should I get tested for aortic valve stenosis?

You should get tested if you experience symptoms like chest pain or pressure during physical activity, shortness of breath with exertion or when lying down, fatigue, dizziness, or fainting episodes. Testing is also important if you have a heart murmur detected during a physical exam, a family history of heart valve disease, or known risk factors like high cholesterol or elevated lipoprotein(a) levels. If you were born with a bicuspid aortic valve or had rheumatic fever as a child, regular monitoring is essential even without symptoms, as these conditions significantly increase your risk for developing stenosis over time.

What are the symptoms of aortic valve stenosis?
Aortic valve stenosis symptoms often develop gradually as the valve narrows over time. Common symptoms include chest pain or tightness during physical activity, shortness of breath especially with exertion or when lying flat, unusual fatigue during normal activities, dizziness or lightheadedness, and fainting episodes particularly during exercise. You might also notice heart palpitations, rapid or fluttering heartbeat, or swollen ankles and feet as the condition progresses. Many people have no symptoms in the early stages, which is why regular check-ups are important if you have risk factors for heart valve disease.
Who is at risk for aortic valve stenosis?
Older adults over age 65 are at highest risk for aortic valve stenosis due to age-related calcium buildup on the valve. People with elevated lipoprotein(a) levels, high cholesterol, high blood pressure, or diabetes face increased risk because these conditions accelerate valve calcification. Those born with a bicuspid aortic valve, which has two leaflets instead of three, are more likely to develop stenosis at a younger age. Additional risk factors include chronic kidney disease, history of rheumatic fever, radiation therapy to the chest, and family history of heart valve disease.
What happens if aortic valve stenosis is left untreated?
Untreated aortic valve stenosis progressively worsens and can lead to serious heart complications. As the valve continues to narrow, your heart must work harder to pump blood through the restricted opening, eventually causing the heart muscle to weaken and fail. This can result in heart failure with symptoms like severe shortness of breath, fluid buildup in the lungs and legs, and life-threatening arrhythmias. Severe stenosis significantly increases your risk for sudden cardiac death, stroke, and heart attack. Once symptoms develop, survival rates decline rapidly without treatment, making early detection and monitoring crucial for preventing these potentially fatal complications.
Can aortic valve stenosis be diagnosed with a blood test?
Aortic valve stenosis cannot be diagnosed directly with a blood test, but blood work plays an important supporting role in assessment and risk evaluation. The primary diagnostic tool is an echocardiogram, which uses ultrasound to visualize the valve structure, measure the opening size, and assess blood flow. However, the Lipoprotein(a) blood test is valuable for identifying cardiovascular risk factors that contribute to valve calcification and disease progression. This test helps your healthcare provider understand your risk profile and develop strategies to slow stenosis progression, even though imaging studies remain essential for confirming the diagnosis and determining severity.
How is aortic valve stenosis treated?
Aortic valve stenosis treatment depends on the severity of your condition and symptoms. Mild stenosis without symptoms typically requires regular monitoring with echocardiograms and managing risk factors like high cholesterol and elevated lipoprotein(a) levels. Moderate to severe stenosis usually requires valve replacement, either through open-heart surgery or a minimally invasive procedure called transcatheter aortic valve replacement, where a new valve is inserted through a catheter. Medications cannot cure stenosis but may help manage symptoms and related conditions like high blood pressure or heart failure. Your cardiologist will recommend the best treatment approach based on your valve function, symptoms, and overall health.
How can I prevent aortic valve stenosis?
While you cannot prevent congenital valve defects or age-related changes, you can slow stenosis progression by managing cardiovascular risk factors. Maintain healthy cholesterol levels through diet and medication if needed, as high cholesterol accelerates valve calcification. Control blood pressure and blood sugar if you have diabetes, and avoid smoking, which damages blood vessels and heart valves. Regular exercise and a heart-healthy diet rich in fruits, vegetables, and whole grains support overall cardiovascular health. Get prompt treatment for strep throat infections to prevent rheumatic fever, and attend regular check-ups if you have risk factors or a family history of heart valve disease.
What can I do at home for aortic valve stenosis?
At home, focus on heart-healthy lifestyle changes that support cardiovascular health and slow disease progression. Follow a Mediterranean-style diet rich in omega-3 fatty acids, fresh vegetables, fruits, and whole grains while limiting saturated fats and processed foods. Stay physically active with your doctor's approval, but avoid sudden intense exertion that could trigger symptoms. Monitor your symptoms daily and report any changes like increased shortness of breath or chest pain to your healthcare provider immediately. Take all prescribed medications as directed, maintain a healthy weight, manage stress through relaxation techniques, and get adequate sleep. Limit alcohol consumption and avoid smoking or secondhand smoke exposure.
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