Acute HIV Syndrome Blood Test

What is Acute HIV syndrome?

Acute HIV syndrome is the earliest stage of HIV infection that occurs 2-4 weeks after exposure to the virus. It is caused by rapid replication of the Human Immunodeficiency Virus throughout the body, resulting in extremely high viral loads. The HIV 1/2 Antigen and Antibodies Fourth Generation test is the most important test for diagnosis because it detects both viral antigens and antibodies during this critical early phase.

RECOMMENDED TEST HIV 1/2 Antigen and Antibodies, Fourth Generation
What's included
Fast & easy, results by email & SMS
No extra fees paid at the lab
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
Why Private MD Labs?
90-day money-back guarantee Lab order in minutes Save a trip to the doctor Low prices since 2005 Labs within 2 miles

What causes acute HIV syndrome?

Acute HIV syndrome is caused by the Human Immunodeficiency Virus (HIV-1 or HIV-2) entering the body and rapidly multiplying throughout the bloodstream and lymphatic system. After initial exposure through sexual contact, blood exposure, or needle sharing, the virus attacks CD4+ T cells, which are critical components of the immune system. During this acute phase, which occurs 2-4 weeks after infection, viral replication is at its peak, producing extremely high concentrations of the virus in the blood and making this the most contagious stage of HIV infection.

What is the best test for acute HIV syndrome?

The HIV 1/2 Antigen and Antibodies Fourth Generation test is the most important test for acute HIV syndrome because it detects both HIV antigens (specifically the p24 antigen protein produced by the virus) and HIV antibodies simultaneously. This dual detection capability is essential during acute infection because viral antigens appear in the blood 1-3 weeks before antibodies develop, providing a critical early detection window. Fourth-generation testing can identify HIV infection as early as 2-4 weeks after exposure, significantly earlier than older antibody-only tests, allowing for prompt initiation of antiretroviral therapy during this highly infectious stage.

When should I get tested for acute HIV syndrome?

You should get tested if you have had unprotected sexual contact, shared needles, or had any potential exposure to HIV within the past 2-6 weeks, especially if you are experiencing flu-like symptoms such as fever, sore throat, rash, swollen lymph nodes, or extreme fatigue. Testing is also essential if a sexual partner has disclosed their HIV-positive status or if you have experienced occupational exposure through needlestick injuries. Because acute HIV syndrome represents the most contagious stage with the highest viral loads, early testing within 2-4 weeks of potential exposure is critical for starting treatment quickly and preventing transmission to others.

What are the symptoms of acute HIV syndrome?
Acute HIV syndrome typically causes flu-like symptoms including high fever, severe sore throat, persistent headaches, extreme fatigue, swollen lymph nodes in the neck and groin, body aches, and a distinctive red rash that may appear on the torso. You might also experience night sweats, mouth ulcers, diarrhea, and sudden weight loss. These symptoms usually appear 2-4 weeks after exposure and can last anywhere from a few days to several weeks. However, some people experience no symptoms at all during acute infection, which is why blood testing after potential exposure is the only reliable way to confirm HIV status.
Who is at risk for acute HIV syndrome?
Anyone who has had unprotected sexual contact with someone whose HIV status is unknown or positive is at risk, particularly men who have sex with men, people with multiple sexual partners, and individuals who do not consistently use condoms. People who share needles or injection drug equipment face significantly elevated risk. Healthcare workers with needlestick injuries, infants born to HIV-positive mothers, and individuals who have received blood transfusions in countries with inadequate screening protocols are also at risk. Having other sexually transmitted infections increases susceptibility to HIV transmission during exposure.
What happens if acute HIV syndrome is left untreated?
If acute HIV syndrome is left untreated, the infection progresses through chronic HIV infection and eventually develops into AIDS (Acquired Immunodeficiency Syndrome), typically within 8-10 years. During untreated acute infection, the virus destroys CD4+ T cells, progressively weakening the immune system and making you vulnerable to opportunistic infections like pneumonia, tuberculosis, and certain cancers. The extremely high viral loads during acute HIV syndrome also make transmission to others much more likely. Starting antiretroviral therapy during the acute phase can preserve immune function, reduce viral load to undetectable levels, prevent progression to AIDS, and eliminate the risk of sexual transmission.
Can acute HIV syndrome be diagnosed with a blood test?
Acute HIV syndrome can be diagnosed with a blood test, specifically the fourth-generation HIV test that detects both HIV antigens and antibodies. This test can identify acute infection as early as 2-4 weeks after exposure by detecting the p24 antigen, which appears in the blood before antibodies develop. Blood tests measure viral antigens, antibody responses, and in some cases viral load (the amount of HIV RNA in the blood). Older antibody-only tests may miss acute infection because they cannot detect the virus until antibodies develop 3-12 weeks after exposure, which is why fourth-generation testing is the gold standard for early detection.
How is acute HIV syndrome treated?
Acute HIV syndrome is treated with immediate initiation of antiretroviral therapy (ART), which typically consists of a combination of three or more medications that work together to suppress viral replication. Starting treatment during the acute phase provides the best long-term outcomes by preserving immune system function and reducing the viral reservoir in the body. Modern ART regimens are highly effective, usually involving once-daily pills that reduce viral load to undetectable levels within 3-6 months. Early treatment during acute infection also significantly reduces the risk of transmitting HIV to others and may allow for better immune system recovery compared to starting treatment later.
How can I prevent acute HIV syndrome?
You can prevent acute HIV syndrome by using condoms consistently and correctly during every sexual encounter, reducing the number of sexual partners, and getting tested regularly for HIV and other sexually transmitted infections. Pre-exposure prophylaxis (PrEP) is a highly effective preventive medication for people at high risk, reducing HIV transmission by more than 99% when taken as prescribed. Never share needles or injection equipment, and if you are a healthcare worker, follow strict safety protocols to prevent needlestick injuries. If you have potential exposure to HIV, post-exposure prophylaxis (PEP) must be started within 72 hours to prevent infection.
What can I do at home to support my health if I have acute HIV syndrome?
If you have acute HIV syndrome, prioritize rest and stay well-hydrated to help your body manage the flu-like symptoms during this phase. Eat nutritious, balanced meals with plenty of fruits, vegetables, lean proteins, and whole grains to support your immune system. Avoid alcohol and recreational drugs, which can weaken immunity and interfere with medications. Practice safe sex and disclose your status to sexual partners to prevent transmission. Most importantly, take all prescribed antiretroviral medications exactly as directed without missing doses, as medication adherence is critical for suppressing the virus. Attend all follow-up appointments to monitor your viral load and CD4 count.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
Choose a checkup
Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
Testosterone 375 ng/dL
Demo results
Normal Optimal 400 - 1000 High
375 ng/dL

What this means

Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

Us vs. Them

Not overhyped or overpriced. Just comprehensive blood testing made simple and for everyone.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

1,000,000+ blood tests later, here's what our customers say

Google reviews 505 reviews Next
HIV 1/2 Antigen and Antibodies, Fourth Generation
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

Sample results

Sample image
For you & your coach Health insights Written in human language, backed by science.
Sample image
For you & your doc Classic lab report A familiar and comprehensive lab report.

Ask Me Anything

Your 24/7 Personal Lab Guide

Quick questions:

Which test is right for my symptoms?
What could be causing this?
When should I get tested?
A

Hi, I'm here to make labs simple, clear, and stress-free. Not sure where to start? That's okay. Tell me what's going on and I'll guide you from there.

I can help you:

  • choose the right test
  • prepare for your lab visit
  • take the next step with confidence and more
Just now
A
Not finding what you need? Text 754-799-7833, we've got you.
We provide helpful guidance, not medical diagnoses. For medical decisions, consult a licensed professional.