What's this test for?

This test is ideal if you're experiencing chronic fatigue that doesn't improve with rest, unexplained mood swings, or concerns about cardiovascular health in your family. It identifies genetic variations in the MTHFR gene that can affect how your body processes folate and manages homocysteine levels, which impacts energy production, mental health, and heart disease risk. Many people use this test when they suspect their persistent symptoms might have a genetic cause or when they have family history of heart disease or blood clots.

What happens after I get my results?

You'll receive detailed doctor notes in simple language explaining what your MTHFR genetic variants mean for your health and whether they may be contributing to your symptoms. These notes include personalized recommendations like specific B-vitamin supplementation strategies, dietary changes to support methylation, and whether you should monitor homocysteine levels. You'll also get the standard lab report, and since this is a one-time genetic test, your results provide permanent insights you can use throughout your life when making health decisions.

What's included in this test?

This test measures the MTHFR gene specifically analyzing the C677T variant and A1298C variant. This genetic test analyzes your MTHFR gene for the two most common variants that affect enzyme function. The C677T variant (also called thermolabile) and A1298C variant are checked to determine if you carry one or both copies of these mutations. Understanding your MTHFR status helps explain potential vulnerabilities in folate metabolism, homocysteine processing, and methylation pathways that influence energy levels, mood regulation, and cardiovascular health.

How should I prepare for this test?

No special preparation is needed for this test. You don't need to fast before your blood draw, and you can take your regular medications and supplements. Since this is a genetic test analyzing your DNA, your results won't change based on what you eat or do beforehand, making it convenient to schedule anytime.

Who should consider getting this test?

This test is valuable for people with unexplained chronic fatigue, persistent mood issues like anxiety or depression, or a family history of heart disease or blood clotting disorders. It's also helpful for women who have experienced recurrent miscarriages, individuals with elevated homocysteine levels, or anyone who hasn't responded well to standard B-vitamin supplements. People with autoimmune conditions or those planning pregnancy may also benefit from understanding their MTHFR status.

What symptoms indicate I may need this test?

Common symptoms that may be related to MTHFR variants include persistent fatigue that doesn't improve with rest, difficulty concentrating or brain fog, mood swings or anxiety, and unexplained irritability. You might also experience headaches or migraines, difficulty getting pregnant or maintaining pregnancy, or have concerns about cardiovascular health. If these symptoms are present along with a family history of heart disease, stroke, or blood clots, this test can provide valuable genetic insights.

How can I naturally support my MTHFR gene function?

If you have MTHFR variants, focus on consuming methylated forms of B vitamins like methylfolate (not regular folic acid) and methylcobalamin (B12) through supplements or fortified foods. Eat plenty of leafy greens, legumes, and whole foods rich in natural folate, and include B6 sources like chickpeas, salmon, and poultry. Reduce stress through regular exercise and adequate sleep, limit alcohol consumption, and avoid processed foods high in synthetic folic acid which may be harder for your body to process.

What is the MTHFR gene and why does it matter?

The MTHFR gene provides instructions for making an enzyme that helps your body process folate (vitamin B9) and convert it into a usable form. This enzyme is crucial for producing neurotransmitters that affect mood, creating DNA, and breaking down homocysteine, an amino acid that at high levels can damage blood vessels. When you have MTHFR gene variants, this enzyme works less efficiently, potentially affecting energy production, mental health, pregnancy outcomes, and cardiovascular health over time.

What does it mean if I have MTHFR mutations?

Having MTHFR mutations means your body may be less efficient at converting folate into its active form and processing homocysteine. If you have one copy of a variant (heterozygous), the impact is typically mild and manageable with dietary adjustments. If you have two copies (homozygous) or variants in both genes (compound heterozygous), enzyme activity may be more significantly reduced, potentially requiring methylated B-vitamin supplementation and closer monitoring of homocysteine levels.

What should I do if my MTHFR test is positive for variants?

If you test positive for MTHFR variants, start by switching to methylated forms of B vitamins rather than synthetic folic acid. Consider having your homocysteine levels tested to see if they're elevated, as this helps determine if the genetic variant is actually impacting your health. Work with a healthcare provider familiar with MTHFR to develop a personalized supplement and nutrition plan, and focus on eating whole foods rich in natural folate while managing stress and maintaining a healthy lifestyle.

Getting your blood test with us is easy, private & backed by the power of science.Long story short: In the test options, use the filters or search box to narrow your choices and find the test you want. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy! If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

How do I know which test to get?

In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option. Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

When will my lab results be available?

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know. After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop! If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Absolutely! We totally understand that errors can happen. No worries, we're here to help you. Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you. There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out. Our lab requires an address to be listed to generate an order.

Do you accept health insurance?

Only HSA & FSA is accepted. Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts. This policy applies to all insurance companies, including federal health insurance programs like Medicare. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Can I cancel my order?

Yes. We get it – sometimes your needs change. As long as your samples haven’t been collected yet, we’re happy to help you cancel your order. If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com. You can read more about our cancellation policy here.

How can I find a lab location near me?

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp). Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

MTHFR Genetic Test - Fatigue & Heart Health

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

754-799-7833

support@privatemdlabs.com

Genetic Test for Chronic Fatigue and Mood Issues

MTHFR Mutation(12) (QSC)

90 day happiness guarantee

Prescription & fees included

Easy to understand results

Fast & convenient

90 day happiness guarantee

Prescription & fees included

Easy to understand results

Fast & convenient

What's this test for?

How should I prepare for this test?

What's included in this test?

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

Genetic Test for Chronic Fatigue and Mood Issues

90 day happiness guarantee

Prescription & fees included

Easy to understand results

Fast & convenient

1,000,000+ blood tests later, here's what our customers say

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